MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis

Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites targeted for H3NT proteolysis and the functional significance of H3NT cleavage remain largely unknown. Here we report the first method to identify...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Kim, Kyunghwan, Punj, Vasu, Kim, Jin-Man, Lee, Sunyoung, Ulmer, Tobias S., Lu, Wange, Rice, Judd C., An, Woojin
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719310/
https://ncbi.nlm.nih.gov/pubmed/26744418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268714.115
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