Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

The Keap1-Nrf2 system plays a central role in cytoprotection against electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major sensor cysteine residues for detecting these stresses, it has not been technically feasible to evaluate the functionality of Cys273 or Cys288,...

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Udgivet i:Mol Cell Biol
Main Authors: Saito, Ryota, Suzuki, Takafumi, Hiramoto, Keiichiro, Asami, Soichiro, Naganuma, Eriko, Suda, Hiromi, Iso, Tatsuro, Yamamoto, Hirotaka, Morita, Masanobu, Baird, Liam, Furusawa, Yuki, Negishi, Takaaki, Ichinose, Masakazu, Yamamoto, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719294/
https://ncbi.nlm.nih.gov/pubmed/26527616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00868-15
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