Keap1 inhibition attenuates glomerulosclerosis

BACKGROUND: NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomeruloscle...

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Main Authors: Miyazaki, Yoichi, Shimizu, Akihiro, Pastan, Ira, Taguchi, Keiko, Naganuma, Eriko, Suzuki, Takafumi, Hosoya, Tatsuo, Yokoo, Takashi, Saito, Akihiko, Miyata, Toshio, Yamamoto, Masayuki, Matsusaka, Taiji
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967835/
https://ncbi.nlm.nih.gov/pubmed/24523358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu002
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