Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of oesophageal Nrf2 in Keap1-null mice allo...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Suzuki, Takafumi, Seki, Shiori, Hiramoto, Keiichiro, Naganuma, Eriko, Kobayashi, Eri H., Yamaoka, Ayaka, Baird, Liam, Takahashi, Nobuyuki, Sato, Hiroshi, Yamamoto, Masayuki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333130/
https://ncbi.nlm.nih.gov/pubmed/28233855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14577
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars