Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of oesophageal Nrf2 in Keap1-null mice allo...

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Udgivet i:Nat Commun
Main Authors: Suzuki, Takafumi, Seki, Shiori, Hiramoto, Keiichiro, Naganuma, Eriko, Kobayashi, Eri H., Yamaoka, Ayaka, Baird, Liam, Takahashi, Nobuyuki, Sato, Hiroshi, Yamamoto, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333130/
https://ncbi.nlm.nih.gov/pubmed/28233855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14577
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