Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells

A proliferative endothelial cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH). Bone morphogenetic protein type II receptor (BMPR2) loss-of-function is the most common cause of heritable PAH and has been closely linked to t...

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發表在:Am J Physiol Lung Cell Mol Physiol
Main Authors: Awad, Keytam S., Elinoff, Jason M., Wang, Shuibang, Gairhe, Salina, Ferreyra, Gabriela A., Cai, Rongman, Sun, Junfeng, Solomon, Michael A., Danner, Robert L.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719048/
https://ncbi.nlm.nih.gov/pubmed/26589479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00303.2015
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