G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY

Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been widely used to treat type 2 diabetes mellitus. However, knowledge of PPARγ signaling remains incomplete. In addition to PPARγ, these drugs also activate G protein-coupled receptor 40 (GPR40), a Gα(q)-coupled free fatty acid recep...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Shuibang, Awad, Keytam S., Elinoff, Jason M., Dougherty, Edward J., Ferreyra, Gabriela A., Wang, Jennifer Y., Cai, Rongman, Sun, Junfeng, Ptasinska, Anetta, Danner, Robert L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528122/
https://ncbi.nlm.nih.gov/pubmed/26105050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638924
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