Methionine and S-Adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

BACKGROUND & AIMS: Glycine N-methyltransferase (GNMT) expression is decreased in some patients with severe NAFLD. Gnmt deficiency in mice (Gnmt-KO) results in abnormally elevated serum levels of methionine and its metabolite S-adenosylmethionine (SAMe), and this leads to rapid liver steatosis de...

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Pubblicato in:J Hepatol
Autori principali: Zubiete-Franco, Imanol, García-Rodríguez, Juan Luis, Martínez-Uña, Maite, Martínez-Lopez, Nuria, Woodhoo, Ashwin, Juan, Virginia Gutiérrez-De, Beraza, Naiara, Lage-Medina, Sergio, Andrade, Fernando, Fernandez, Marta Llarena, Aldámiz-Echevarría, Luis, Fernández-Ramos, David, Falcon-Perez, Juan Manuel, Lopitz-Otsoa, Fernando, Fernandez-Tussy, Pablo, Barbier-Torres, Lucía, Luka, Zigmund, Wagner, Conrad, García-Monzón, Carmelo, Lu, Shelly C., Aspichueta, Patricia, Mato, José María, Martínez-Chantar, María Luz, Varela-Rey, Marta
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718902/
https://ncbi.nlm.nih.gov/pubmed/26394163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.08.037
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