S-adenosylmethionine levels regulate the Schwann cell DNA methylome

Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. DNA methylation is an essential epigenetic modification during mammalian development, yet its role in myelination r...

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Main Authors: Varela-Rey, Marta, Iruarrizaga-Lejarreta, Marta, Lozano, Juan José, Aransay, Ana María, Fernandez, Agustín F., Lavin, José Luis, Mósen-Ansorena, David, Berdasco, María, Turmaine, Marc, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C., Esteller, Manel, Mirsky, Rhona, Jessen, Kristján R., Fraga, Mario F., Martínez-Chantar, María L., Mato, José M., Woodhoo, Ashwin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960855/
https://ncbi.nlm.nih.gov/pubmed/24607226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.01.037
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