Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes

The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor HoxA9, forms nuclear aggregates that frequent...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Oka, Masahiro, Mura, Sonoko, Yamada, Kohji, Sangel, Percival, Hirata, Saki, Maehara, Kazumitsu, Kawakami, Koichi, Tachibana, Taro, Ohkawa, Yasuyuki, Kimura, Hiroshi, Yoneda, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718815/
https://ncbi.nlm.nih.gov/pubmed/26740045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09540
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