Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust activation of Hox genes (Oka et al., 2016). However, whether this phenomenon is general to other leukemogenic proteins remains...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Oka, Masahiro, Mura, Sonoko, Otani, Mayumi, Miyamoto, Yoichi, Nogami, Jumpei, Maehara, Kazumitsu, Harada, Akihito, Tachibana, Taro, Yoneda, Yoshihiro, Ohkawa, Yasuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874418/
https://ncbi.nlm.nih.gov/pubmed/31755865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46667
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