Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro

The human TAR RNA-binding protein (hTRBP) and protein activator of protein kinase R (hPACT) are important players in RNA interference (RNAi). Together with hArgonaute2 (hAgo2) and hDicer they have been reported to form the RISC-loading complex (RLC). Among other functions, hTRBP was suggested to ass...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Willkomm, Sarah, Deerberg, Andrea, Heidemann, Johannes, Flügge, Friedemann, Meine, Janica, Hu, Rui, Kretschmer-Kazemi Far, Rosel, Restle, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718636/
https://ncbi.nlm.nih.gov/pubmed/26784517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146814
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