Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA

RNA interference (RNAi) is an evolutionally conserved posttranscriptional gene-silencing mechanism whereby small interfering RNA (siRNA) triggers sequence-specific cleavage of its cognate mRNA. Dicer, Argonaute (Ago), and either TAR-RNA binding protein (TRBP) or a protein activator of PKR (PACT) are...

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Main Authors: Takahashi, Tomoko, Miyakawa, Takuya, Zenno, Shuhei, Nishi, Kenji, Tanokura, Masaru, Ui-Tei, Kumiko
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642127/
https://ncbi.nlm.nih.gov/pubmed/23658827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063434
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