Activation loop phosphorylation regulates B‐Raf in vivo and transformation by B‐Raf mutants

Despite being mutated in cancer and RASopathies, the role of the activation segment (AS) has not been addressed for B‐Raf signaling in vivo. Here, we generated a conditional knock‐in mouse allowing the expression of the B‐Raf(AVKA) mutant in which the AS phosphoacceptor sites T599 and S602 are repla...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Köhler, Martin, Röring, Michael, Schorch, Björn, Heilmann, Katharina, Stickel, Natalie, Fiala, Gina J, Schmitt, Lisa C, Braun, Sandra, Ehrenfeld, Sophia, Uhl, Franziska M, Kaltenbacher, Thorsten, Weinberg, Florian, Herzog, Sebastian, Zeiser, Robert, Schamel, Wolfgang W, Jumaa, Hassan, Brummer, Tilman
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718462/
https://ncbi.nlm.nih.gov/pubmed/26657898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592097
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