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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
Engagement of the B-cell antigen receptor (BCR) leads to activation of the Raf–MEK–ERK pathway and Raf kinases play an important role in the modulation of ERK activity. B lymphocytes express two Raf isoforms, Raf-1 and B-Raf. Using an inducible deletion system in DT40 cells, the contribution of Raf-...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131085/ https://ncbi.nlm.nih.gov/pubmed/12411479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf588 |
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