Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

Engagement of the B-cell antigen receptor (BCR) leads to activation of the Raf–MEK–ERK pathway and Raf kinases play an important role in the modulation of ERK activity. B lymphocytes express two Raf isoforms, Raf-1 and B-Raf. Using an inducible deletion system in DT40 cells, the contribution of Raf-...

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Pubblicato in:	EMBO J
Autori principali:	Brummer, Tilman, Shaw, Peter E., Reth, Michael, Misawa, Yukiko
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf588
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