Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
Engagement of the B-cell antigen receptor (BCR) leads to activation of the Raf–MEK–ERK pathway and Raf kinases play an important role in the modulation of ERK activity. B lymphocytes express two Raf isoforms, Raf-1 and B-Raf. Using an inducible deletion system in DT40 cells, the contribution of Raf-...
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| 发表在: | EMBO J |
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| Principais autores: | , , , |
| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
Nature Publishing Group
2002
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| 主题: | |
| 在线阅读: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf588 |
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