Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
Abstract Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kina...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Nature
2011-05-01
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| Series: | Molecular Systems Biology |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1038/msb.2011.27 |
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