Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Abstract Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kina...

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Bibliografski detalji

Glavni autori:	Raphaela Fritsche‐Guenther, Franziska Witzel, Anja Sieber, Ricarda Herr, Nadine Schmidt, Sandra Braun, Tilman Brummer, Christine Sers, Nils Blüthgen
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2011-05-01
Serija:	Molecular Systems Biology
Teme:	expression noise MAPK signalling negative feedback Raf robustness
Online pristup:	https://doi.org/10.1038/msb.2011.27
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