A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression

Cancer cells often adapt to targeted therapies, yet the molecular mechanisms underlying adaptive resistance remain only partially understood. Here, we explore a mechanism of RAS/RAF/MEK/ERK (MAPK) pathway reactivation through the upregulation of RAF isoform (RAFs) abundance. Using computational mode...

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Bibliografiske detaljer

Principais autores:	Hiroaki Imoto, Nora Rauch, Ashish J. Neve, Fahimeh Khorsand, Martina Kreileder, Leonidas G. Alexopoulos, Jens Rauch, Mariko Okada, Boris N. Kholodenko, Oleksii S. Rukhlenko
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2023-08-01
Serier:	Biomolecules
Fag:	MAP Kinases RAF dimerization RAF inhibitor resistance structure-based mechanistic modeling RAF isoforms ARAF knockout
Online adgang:	https://www.mdpi.com/2218-273X/13/8/1212
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