Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-1...

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Vydáno v:Oncotarget
Hlavní autoři: Eisenhardt, Anja E., Sprenger, Adrian, Röring, Michael, Herr, Ricarda, Weinberg, Florian, Köhler, Martin, Braun, Sandra, Orth, Joachim, Diedrich, Britta, Lanner, Ulrike, Tscherwinski, Natalja, Schuster, Simon, Dumaz, Nicolas, Schmidt, Enrico, Baumeister, Ralf, Schlosser, Andreas, Dengjel, Jörn, Brummer, Tilman
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042004/
https://ncbi.nlm.nih.gov/pubmed/27034005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8427
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