Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-1...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Eisenhardt, Anja E., Sprenger, Adrian, Röring, Michael, Herr, Ricarda, Weinberg, Florian, Köhler, Martin, Braun, Sandra, Orth, Joachim, Diedrich, Britta, Lanner, Ulrike, Tscherwinski, Natalja, Schuster, Simon, Dumaz, Nicolas, Schmidt, Enrico, Baumeister, Ralf, Schlosser, Andreas, Dengjel, Jörn, Brummer, Tilman
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042004/
https://ncbi.nlm.nih.gov/pubmed/27034005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8427
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