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A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

α-Methylacyl-CoA racemase (AMACR; P504S) catalyses a key step in the degradation of branched-chain fatty acids and is important for the pharmacological activation of Ibuprofen and related drugs. Levels of AMACR are increased in prostate and other cancers, and it is a drug target. Development of AMAC...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Yevglevskis, Maksims, Lee, Guat L., Sun, Jenny, Zhou, Shiyi, Sun, Xiaolong, Kociok-Köhn, Gabriele, James, Tony D., Woodman, Timothy J., Lloyd, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718014/
https://ncbi.nlm.nih.gov/pubmed/26537174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01541c
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