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A study on the AMACR catalysed elimination reaction and its application to inhibitor testing
α-Methylacyl-CoA racemase (AMACR; P504S) catalyses a key step in the degradation of branched-chain fatty acids and is important for the pharmacological activation of Ibuprofen and related drugs. Levels of AMACR are increased in prostate and other cancers, and it is a drug target. Development of AMAC...
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| 出版年: | Org Biomol Chem |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718014/ https://ncbi.nlm.nih.gov/pubmed/26537174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01541c |
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