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Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

BACKGROUND: Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal ta...

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Bibliographische Detailangaben
Veröffentlicht in:BMC Genomics
Hauptverfasser: Wappett, Mark, Dulak, Austin, Yang, Zheng Rong, Al-Watban, Abdullatif, Bradford, James R., Dry, Jonathan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717622/
https://ncbi.nlm.nih.gov/pubmed/26781748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2375-1
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