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Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs
BACKGROUND: Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal ta...
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| Publié dans: | BMC Genomics |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4717622/ https://ncbi.nlm.nih.gov/pubmed/26781748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2375-1 |
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