Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over 600 LUAD. Here we provide evidence that co-occurrence o...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Unni, Arun M, Lockwood, William W, Zejnullahu, Kreshnik, Lee-Lin, Shih-Queen, Varmus, Harold
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2015
Konular:
Human Biology and Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478584/
https://ncbi.nlm.nih.gov/pubmed/26047463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06907
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