Intact endothelial autophagy is required to maintain vascular lipid homeostasis

The physiological role of autophagic flux within the vascular endothelial layer remains poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL stimulates autophagosome formation. Moreover, by both confocal and electron microscopy, excess native or modified LDL ap...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Torisu, Kumiko, Singh, Krishna K., Torisu, Takehiro, Lovren, Fina, Liu, Jie, Pan, Yi, Quan, Adrian, Ramadan, Azza, Al‐Omran, Mohammed, Pankova, Natalie, Boyd, Shelley R., Verma, Subodh, Finkel, Toren
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Short Takes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717267/
https://ncbi.nlm.nih.gov/pubmed/26780888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12423
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