Intact endothelial autophagy is required to maintain vascular lipid homeostasis

The physiological role of autophagic flux within the vascular endothelial layer remains poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL stimulates autophagosome formation. Moreover, by both confocal and electron microscopy, excess native or modified LDL ap...

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Bibliographic Details
Published in:	Aging Cell
Main Authors:	Torisu, Kumiko, Singh, Krishna K., Torisu, Takehiro, Lovren, Fina, Liu, Jie, Pan, Yi, Quan, Adrian, Ramadan, Azza, Al‐Omran, Mohammed, Pankova, Natalie, Boyd, Shelley R., Verma, Subodh, Finkel, Toren
Format:	Artigo
Language:	Inglês
Published:	John Wiley and Sons Inc. 2015
Subjects:	Short Takes
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4717267/ https://ncbi.nlm.nih.gov/pubmed/26780888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12423
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Intact endothelial autophagy is required to maintain vascular lipid homeostasis

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