Intact endothelial autophagy is required to maintain vascular lipid homeostasis

The physiological role of autophagic flux within the vascular endothelial layer remains poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL stimulates autophagosome formation. Moreover, by both confocal and electron microscopy, excess native or modified LDL ap...

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Publicado en:Aging Cell
Autores principales: Torisu, Kumiko, Singh, Krishna K., Torisu, Takehiro, Lovren, Fina, Liu, Jie, Pan, Yi, Quan, Adrian, Ramadan, Azza, Al‐Omran, Mohammed, Pankova, Natalie, Boyd, Shelley R., Verma, Subodh, Finkel, Toren
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Short Takes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717267/
https://ncbi.nlm.nih.gov/pubmed/26780888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12423
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