Intact endothelial autophagy is required to maintain vascular lipid homeostasis

The physiological role of autophagic flux within the vascular endothelial layer remains poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL stimulates autophagosome formation. Moreover, by both confocal and electron microscopy, excess native or modified LDL ap...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Torisu, Kumiko, Singh, Krishna K., Torisu, Takehiro, Lovren, Fina, Liu, Jie, Pan, Yi, Quan, Adrian, Ramadan, Azza, Al‐Omran, Mohammed, Pankova, Natalie, Boyd, Shelley R., Verma, Subodh, Finkel, Toren
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717267/
https://ncbi.nlm.nih.gov/pubmed/26780888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12423
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