Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis

Polyketides, such as erythromycin, are complex natural products with diverse therapeutic applications. They are synthesized by multi-modular megaenzymes, so-called polyketide synthases (PKSs). The macrolide core of erythromycin, 6-deoxyerythronolide B (6dEB), is produced by the deoxyerythronolide B...

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Bibliographic Details
Published in:Appl Microbiol Biotechnol
Main Authors: Kumpfmüller, Jana, Methling, Karen, Fang, Lei, Pfeifer, Blaine A., Lalk, Michael, Schweder, Thomas
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
Biotechnological Products and Process Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717160/
https://ncbi.nlm.nih.gov/pubmed/26432460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-015-6990-6
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