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Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus
Three-dimensional genome structure plays an important role in gene regulation. Globally, chromosomes are organized into active and inactive compartments while, at the gene level, looping interactions connect promoters to regulatory elements. Topologically associating domains (TADs), typically severa...
Enregistré dans:
| Publié dans: | Am J Hum Genet |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4716690/ https://ncbi.nlm.nih.gov/pubmed/26748519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.12.002 |
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