Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus

The regulated expression of large human genes can depend on long-range interactions to establish appropriate three-dimensional structures across the locus. The cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encompasses 189 kb of genomic DNA, shows a complex pattern of express...

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Bibliografische gegevens
Hoofdauteurs: Ott, Christopher J., Blackledge, Neil P., Kerschner, Jenny L., Leir, Shih-Hsing, Crawford, Gregory E., Cotton, Calvin U., Harris, Ann
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785270/
https://ncbi.nlm.nih.gov/pubmed/19897727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900946106
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