A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

The binding of the transcriptional regulator CTCF to the genome has been implicated in the formation of topologically associated domains (TADs). However, the general mechanisms of folding the genome into TADs are not fully understood. Here we test the effects of deleting a CTCF-rich locus on TAD bou...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Barutcu, A. Rasim, Maass, Philipp G., Lewandowski, Jordan P., Weiner, Catherine L., Rinn, John L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899154/
https://ncbi.nlm.nih.gov/pubmed/29654311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03614-0
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