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A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
The binding of the transcriptional regulator CTCF to the genome has been implicated in the formation of topologically associated domains (TADs). However, the general mechanisms of folding the genome into TADs are not fully understood. Here we test the effects of deleting a CTCF-rich locus on TAD bou...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899154/ https://ncbi.nlm.nih.gov/pubmed/29654311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03614-0 |
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