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Sonic Hedgehog signaling drives mitochondrial fragmentation by suppressing mitofusins in cerebellar granule neuron precursors and medulloblastoma

Sonic hedgehog (Shh) signaling is closely coupled with bioenergetics of medulloblastoma, the most common malignant pediatric brain tumor. Shh-associated medulloblastoma arises from cerebellar granule neuron precursors (CGNPs), a neural progenitor whose developmental expansion requires signaling by S...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Res
Huvudupphovsmän: Malhotra, Anshu, Dey, Abhinav, Prasad, Niyathi, Kenney, Anna Marie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715946/
https://ncbi.nlm.nih.gov/pubmed/26446920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0278
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