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Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors

Epoxyketone proteasome inhibitors have attracted much interest due to their potential as anti-cancer drugs. While the biosynthetic gene clusters for several peptidyl epoxyketone natural products have recently been identified, the enzymatic logic involved in the formation of the terminal epoxyketone...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Liu, Joyce, Zhu, Xuejun, Zhang, Wenjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715529/
https://ncbi.nlm.nih.gov/pubmed/26477320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500496
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