Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study of bacterial biosynthesis, enabling the targeted isolation of previously unidentified natural products directly from complex metagenomes. Our...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Owen, Jeremy G., Charlop-Powers, Zachary, Smith, Alexandra G., Ternei, Melinda A., Calle, Paula Y., Reddy, Boojala Vijay B., Montiel, Daniel, Brady, Sean F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394318/
https://ncbi.nlm.nih.gov/pubmed/25831524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501124112
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