Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

Complex microbial ecosystems contain large reservoirs of unexplored biosynthetic diversity. Here we provide an experimental framework and data analysis tool to facilitate the targeted discovery of natural-product biosynthetic gene clusters from the environment. Multiplex sequencing of barcoded PCR a...

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Autors principals: Owen, Jeremy G., Reddy, Boojala Vijay B., Ternei, Melinda A., Charlop-Powers, Zachary, Calle, Paula Y., Kim, Jeffrey H., Brady, Sean F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718090/
https://ncbi.nlm.nih.gov/pubmed/23824289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222159110
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