Two Na(+) Sites Control Conformational Change in a Neurotransmitter Transporter Homolog

In LeuT, a prokaryotic homolog of neurotransmitter transporters, Na(+) stabilizes outward-open conformational states. We examined how each of the two LeuT Na(+) binding sites contributes to Na(+)-dependent closure of the cytoplasmic pathway using biochemical and biophysical assays of conformation. M...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tavoulari, Sotiria, Margheritis, Eleonora, Nagarajan, Anu, DeWitt, David C., Zhang, Yuan-Wei, Rosado, Edwin, Ravera, Silvia, Rhoades, Elizabeth, Forrest, Lucy R., Rudnick, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714228/
https://ncbi.nlm.nih.gov/pubmed/26582198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692012
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