Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot

The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by bioinformatics-based siRNA design is a challe...

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Vydáno v:PLoS One
Hlavní autoři: Moon, Jae-Su, Lee, Seung-Hoon, Kim, Eun-Jung, Cho, Hee, Lee, Wooseong, Kim, Geon-Woo, Park, Hyun-Ji, Cho, Seung-Woo, Lee, Choongho, Oh, Jong-Won
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713436/
https://ncbi.nlm.nih.gov/pubmed/26751678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146710
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