Phosphorylation of Hepatitis C Virus RNA Polymerases Ser29 and Ser42 by Protein Kinase C-Related Kinase 2 Regulates Viral RNA Replication

Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), an RNA-dependent RNA polymerase (RdRp), is the key enzyme for HCV RNA replication. We previously showed that HCV RdRp is phosphorylated by protein kinase C-related kinase 2 (PRK2). In the present study, we used biochemical and reverse-genetics...

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Autores principales: Han, Song-Hee, Kim, Seong-Jun, Kim, Eun-Jung, Kim, Tae-Eun, Moon, Jae-Su, Kim, Geon-Woo, Lee, Seung-Hoon, Cho, Kun, Yoo, Jong Shin, Son, Woo Sung, Rhee, Jin-Kyu, Han, Seung Hyun, Oh, Jong-Won
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178806/
https://ncbi.nlm.nih.gov/pubmed/25031343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01826-14
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