Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks

Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork collapse at ICLs. While lesions different from...

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Udgivet i:PLoS Genet
Main Authors: Federico, María Belén, Vallerga, María Belén, Radl, Analía, Paviolo, Natalia Soledad, Bocco, José Luis, Di Giorgio, Marina, Soria, Gastón, Gottifredi, Vanesa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712966/
https://ncbi.nlm.nih.gov/pubmed/26765540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005792
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