Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs) that accumulate due to the homologous recombin...

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Bibliografske podrobnosti
izdano v:Genet Mol Biol
Main Authors: Paviolo, Natalia Soledad, de la Vega, María Belén, Pansa, María Florencia, García, Iris Alejandra, Calzetta, Nicolás Luis, Soria, Gastón, Gottifredi, Vanesa
Format: Artigo
Jezik:Inglês
Izdano: Sociedade Brasileira de Genética 2019
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198003/
https://ncbi.nlm.nih.gov/pubmed/31930278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-4685-GMB-2019-0070
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