Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

Reprogrammed glucose metabolism is an emerging hallmark of cancer cells, which show a unique metabolic phenotype known as the Warburg effect. Lactate dehydrogenase A (LDHA), a key enzyme in the glycolytic process, executes the final step by conversion of lactate into pyruvate. However, little is kno...

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Bibliographic Details
Published in:Neuroreport
Main Authors: Li, Juan, Zhu, Shuchai, Tong, Jing, Hao, Hui, Yang, Jie, Liu, Zhikun, Wang, Yuxiang
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2016
Subjects:
Cellular, Molecular and Developmental Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712768/
https://ncbi.nlm.nih.gov/pubmed/26694942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000000506
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