Germline quality control: eEF2K stands guard to eliminate defective oocytes

The control of germline quality is critical to reproductive success and survival of a species; however, the mechanisms underlying this process remain unknown. Here we demonstrate that elongation factor 2 kinase (eEF2K), an evolutionarily conserved regulator of protein synthesis, functions to maintai...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Chu, Hsueh-Ping, Liao, Yi, Novak, James S., Hu, Zhixian, Merkin, Jason J., Shymkiv, Yuriy, Braeckman, Bart P., Dorovkov, Maxim V., Nguyen, Alexandra, Clifford, Peter M., Nagele, Robert G., Harrison, David E., Ellis, Ronald E., Ryazanov, Alexey G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712648/
https://ncbi.nlm.nih.gov/pubmed/24582807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.01.027
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