Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study

BACKGROUND AND OBJECTIVE: Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity o...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Derungs, Adrian, Donzelli, Massimiliano, Berger, Benjamin, Noppen, Christoph, Krähenbühl, Stephan, Haschke, Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2015
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712254/
https://ncbi.nlm.nih.gov/pubmed/26123704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0294-y
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