Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin. While assessing CYP2D6 activity under basal conditions and after pre-treatment with rifampicin in vivo, we surprisingl...

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Publicado en:Front Pharmacol
Autores principales: Berger, Benjamin, Bachmann, Fabio, Duthaler, Urs, Krähenbühl, Stephan, Haschke, Manuel
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066528/
https://ncbi.nlm.nih.gov/pubmed/30087611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00774
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