Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2

Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the act...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Bachmann, Fabio, Duthaler, Urs, Meyer zu Schwabedissen, Henriette E., Puchkov, Maxim, Huwyler, Jörg, Haschke, Manuel, Krähenbühl, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247900/
https://ncbi.nlm.nih.gov/pubmed/33336382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2141
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