Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2

Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the act...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Pharmacol Ther
Prif Awduron: Bachmann, Fabio, Duthaler, Urs, Meyer zu Schwabedissen, Henriette E., Puchkov, Maxim, Huwyler, Jörg, Haschke, Manuel, Krähenbühl, Stephan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2021
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247900/
https://ncbi.nlm.nih.gov/pubmed/33336382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2141
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