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Concise Total Synthesis of Trichodermamides A, B and C Enabled by an Efficient Construction of the 1,2-Oxazadecaline Core

We report herein a facile and efficient method of the construction of the cis-1,2-oxazadecaline system, distinctive of (pre)trichodermamides, aspergillazine A, gliovirin and FA-2097. The formation of the 1,2-oxazadecaline core was accomplished by a 1,2-addition of an αC-lithiated O-silyl ethyl pyruv...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Mfuh, Adelphe M., Zhang, Yu, Stephens, David E., Vo, Anh X. T., Arman, Hadi D., Larionov, Oleg V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711935/
https://ncbi.nlm.nih.gov/pubmed/26084356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05205
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