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Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues

The trichodermamides are modified dipeptides isolated from a wide variety of fungi, including Trichoderma virens. Previous studies reported that trichodermamide B (2) initiated cytotoxicity in HCT-116 colorectal cancer cells, while trichodermamide A (1) was devoid of activity. We recently developed...

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Bibliografiske detaljer
Udgivet i:J Nat Prod
Main Authors: Jans, Petra E., Mfuh, Adelphe M., Arman, Hadi D., Shaffer, Corena V., Larionov, Oleg V., Mooberry, Susan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737773/
https://ncbi.nlm.nih.gov/pubmed/28051860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.6b00963
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